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Phentermine is a drug that suppresses appetite and its particular mechanism of action is unknown. It probably decreases appetite by acting on centers in the brain that control appetite of an individual. Phentermine is similar to amphetamine and it acts by stimulating the nervous system, elevates blood pressure, and increases heart rate. Phentermine medication should be stored in a tight container at room temperature because this drug is very sensitive.
Phentermine is combined with diet and exercise for the short-term treatment of obesity in individuals with a body mass index greater than or equal to 30 kg/m2 or more than or equal to 27 kg/m2 with risk factors for cardiovascular diseases. Phentermine should not be taken with other weight loss agents and the combination of phentermine and fenfluramine is associated with serious heart problems. Fenfluramine drug is no longer available in the United States market.
The recommended dose is 30 mg once daily about 2 hours after breakfast and evening doses should be avoided because phentermine leads to insomnia.
Phentermine is mechanism of action is similar to amphetamine and may share some of the common interactions associated with amphetamines. Combining phentermine with tricyclic antidepressants or monoamine oxidase inhibitors may result in elevated blood pressure and other serious reactions because of elevated serotonin levels in the blood. The administration of phentermine during pregnancy has not been adequately evaluated and it is not known whether phentermine is excreted in human breast milk.
The adverse effects of phentermine include nausea, vomiting, diarrhea, dry mouth, constipation, an unpleasant taste, hives, impotence, palpitations, high blood pressure, and fast heart rates. Central nervous system adverse effects include hyperactivity, insomnia, restlessness, tremor, and dizziness. Phentermine, especially when taken in combination with fenfluramine, has been connected with high pressures in the pulmonary arteries and defects in heart valves, both serious complications.